Natasa Pilides holds a degree in Modern Languages from the University of Oxford and is a Fellow of the Institute of Chartered Accountants of England and Wales. She was Director General of Invest Cyprus (the Cyprus Investment Promotion Agency) from 2016 to 2018, then became Cyprus's first Deputy Minister of Shipping, serving from 2018 to 2020.
In July 2020 she was appointed Minister of Energy, Commerce and Industry, a post she held until March 2023. She later joined the board of AstroBank in November 2024 and became Chief Executive Officer of Med Energywise Ltd in March 2025.
She was a panellist at Mare Forum's 5th Mare Forum Cyprus forum in 2016 and 19th Mare Forum Greece forum in 2019.